A SECRET WEAPON FOR PKRRATING

The interfacial residues are really conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations guidance a design where activating RNA serves to be a scaffold to bind many PKR monomers, growing the are

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